摘要
癌细胞与细胞外基质 (ECM)的粘附是恶性肿瘤侵袭首要步骤。肿瘤细胞与细胞外基质的粘附是通过细胞膜表面的特异受体介导的 ,其中整合素家族为重要的粘附分子。对整合素表达相关的细胞外基质的介绍及肝癌细胞侵袭与转移中整合素研究的综述 ,可了解相关的整合素所介导肝癌细胞与细胞外基质、肝癌细胞之间的相互作用。文中提及肝癌细胞趋化运动中相关的整合素 ,有助于进一步了解整合素在肝癌侵袭与转移中的作用。整合素参与了整个肝癌细胞的侵袭转移过程。寻找出干扰整合素与配体相互作用、特异性增加或减少整合素在肿瘤中的表达的物质 ,从而阻断肿瘤的侵袭与转移 。
This is the first key step of carcinoma cells attachment to the extracellular matrix (ECM), which is mediated by the special receptors of cell's exterior. Integrins belong to the most important attachment molecular. A brief review on hepatocellular carcinoma (HCC) cells' integrins & ECM pertinent during invasion and metastasis is given. The recognition of integrins mediating HCC cell-cell adhesion & HCC cells attachment to ECM and integrins' expression during chemotaxis helps us to understand the significant role of integrins during the whole process. The integrins relate to the process of HCC' invasion and metastasis. People are looking forward to anti-integrins so as to interdict or weaken the reciprocity between integrins & ligands, which must bring aspiring effect to the research on anti-cancer medicine.
出处
《重庆大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2002年第6期98-101,共4页
Journal of Chongqing University
基金
国家自然科学基金资助项目 (3 9970 198)
高等学校重点实验室访问学者基金资助项目 (校科字 [2 0 0 2 ] 4号 )
关键词
肝细胞癌细胞
侵袭
转移
整合素
粘附
趋化
hepatocellular carcinoma cells
invasion
metastasis
integrin
adhesion
chemotaxis
