摘要
目的评价内镜下组织粘合剂α-氰丙烯酸正辛酯(D-TH液)治疗食管胃静脉曲张出血的临床疗效。方法将食管胃静脉曲张出血患者57例分成两组,A组的21例经内镜注射D-TH液,B组36例经内镜注射Histoacryl液,术后分别奥曲肽每天0.6mg静脉点滴2～3d。结果A组的急性出血者即时止血率为100%(10/10),B组为100%(17/17);两组的2周再出血率分别为5.0%(1/20)和2.8%(1/36)(P>0.05);3个月再出血率分别为5.0%(1/20)和8.6%(3/35)(P>0.05)。两组均未见明显并发症及副反应。粘合剂D-TH液原液注射法注射针堵塞发生率低于Histaocryl三明治注射法。结论粘合剂D-TH液原液注射法操作较简便,控制出血迅速有效,并发症发生率低,可在临床处理中应用。
Objective To evaluate the clinical efficacy of endoscopic injection of tissue adhesive N-oclyl-α-cyanoacrylate (D-TH) for hemostasis of esophagogastric varices bleeding. Methods Fifty-seven cases of liver cirrhosis with acute esophageal and/or gastric varices bleeding were divided into two groups. Twenty-one cases of group A received D- TH injection under endoscopy.Thirty-six cases of Group B received N-butyl-2-cyanoacrylate (Histoacryl) injection under endoscopy .All patients in both groups followed by Octreotide (daily 0.6 mg) administered intravenously for 3 continuous days. Results The instantaneous hemostatic rates of group A and B were both 100%. In group A and B,the bleeding recurrence rates within two weeks and three months were 5.0%(1/20), 2.8%(1/36) and 5.0%(1/20), 8.6%(3/35) respectively,P >0.05. No marked side effects and complication were found. The obliterate rate of needles for D-TH direct injection is lower than that of Histoacryl sandwich method. Conclusion Tissue adhesive D-TH injection for hemostasis of acute esophagogastric varices bleeding was an effective treatment and was easy to perform without side effects, and could be served as a recommended application in clinics.
出处
《中华消化内镜杂志》
2002年第3期142-144,共3页
Chinese Journal of Digestive Endoscopy
