摘要
沙利度胺（反应停）,最初在欧洲作为镇静剂用于临床,因其有止吐作用,被大量用于孕妇。1961年,明确发现沙利度胺可引起婴儿海豹肢畸形及无肢畸形,导致该药迅速撤出市场。随后的研究发现,沙利度胺对许多免疫失调引起的疾病有治疗效果,如HIV诱导的疮疹性口腔炎、白塞氏综合征、移植物抗宿主病（GVHD）、难治性克隆病及肿瘤等。本文就沙利度胺的多种药理作用、新的临床应用以及药物不良反应作一综述。
Thalidomide was originally marketed as a sedative, which could relieve pregnant women's vomiting. It was removed from the market in 1961 after it was associated with an epidemic of severe birth defects: phocomelia and amelia. Recently, thalidomide has been shown to have therapeutic efficacy in a number of disorders characterized by immune dysregulation, including human immunodeficiency virus infection, Behcet's syndrome, graft versus host disease, refractory Crohn's disease, tumor, and so on. This article reviews the numerous pharmacological effects, the new therapies in clinic, and the side effects of thalidomide.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2002年第3期232-235,共4页
The Chinese Journal of Clinical Pharmacology
