摘要
目的 :研究氧化砷对移植性腹水型肝癌细胞的抗癌作用。方法 :肝癌细胞 (1 8× 10 7)接种入小鼠腹腔。对照组注射NS(0 8mL) ,余组用氧化砷 (1,2 ,3μmol/L)腹腔注射 ,每日 1次 ,共 10日。结果 :第 10天腹水细胞计数 ,1,2和 3μmol/L组瘤细胞锐减 (P <0 0 5 ) ,但第 16天腹水肿瘤细胞急骤增加。结论 :氧化砷对腹水肿瘤细胞有暂时抑制作用。
Objective: To study the anticancerous action of arsenic trioxide (As 2O 3) on transplantated ascite hepatic carcinoma cells. Methods: The hepatic carcinoma cells(1.8×10 7)were inoculated into the intraperitoneal cavity of mice. NS(0.8mL)was injected in control group.As 2O 3 in 1, 2, 3μmol/L was injected into the intraperitoneal cavity respectively once a day for 10 days in other groups. Results: Ascitic_type tumor cells were calculated at the 10th and 16th day. As 2O 3 in 1, 2, 3μmol/L induced a marked decrease in the number of tumor cells at the 10th day (P<0.05), but increased sharply at the 16th day. In the 1μmol/L As 2O 3 group, tumor cell numbers slightly increased. Conclusion: Arsenic trioxide can inhibit cell growth temporarily in ascitic_type hepatic carcinoma cells
出处
《汕头大学医学院学报》
2002年第2期68-70,共3页
Journal of Shantou University Medical College
基金
广东省中医药局资助课题 ( 10 0 0 83)
