摘要
目的 探讨促超排卵周期外周血瘦素 (Leptin)水平的变化、穿卵时卵泡液Leptin水平与同步外周血Leptin水平之间的关系。 方法 采用酶联免疫吸附试验 (ELISA)检测 1 8例不孕患者、2 1个促超排卵周期不同阶段外周血、卵泡液Leptin水平及对照组排卵前外周血Leptin水平。结果 促超排卵周期中应用GnRH a卵巢功能被最大抑制时外周血Leptin水平最低 ,穿卵前显著升高 (P <0 .0 0 1 ) ;促超排卵患者穿卵前外周血Leptin水平高于正常对照组排卵前Leptin水平(P <0 .0 5 ) ;卵泡液Leptin水平与同步外周血Leptin水平呈正相关 (r=0 .947,P <0 .0 5 )。结论①卵巢功能与Leptin之间相互影响 ;
Objective To study the relationship of leptin levels in the peripheral blood in the cycle of the controlled ovarian hyperstimulation (COH), the follicular fluid and peripheral blood at the time of follicular puncture. Methods By using ELISA, we selected 18 patients who suffered from infertility. The leptin levels in their peripheral blood and follicular fluid were measured 21 times during different periods of COH. Finally we tested the blood leptin in the cycle before ovulation in the control group. Result During the period of COH, the blood leptin was found at the lowest level. When we used GnRH a on the patients in order to best restrain the function of their ovaries, it increased remarkably before the follicular puncture. The blood leptin level of the patients under COH treatment before their follicular puncture was higher than that of the control group before ovulation ( P < 0.05 ). Conclusion ① There is a positive correlation between ovarian function and leptin; ② There is a positive correlation between leptin in peripheral blood and follicular fluid.
出处
《西安医科大学学报》
CAS
CSCD
北大核心
2002年第3期293-295,共3页
Journal of Xi'an Medical University(Chinese)
基金
西安交通大学第一医院科研基金资助
