摘要
目的 :观察胆酸和甘草甜素致高血压作用及其可能机制。方法 :给大鼠口服胆酸 1周及 5周、口服甘草甜素 6周 ,观察大鼠血压及肠系膜动脉对去甲肾上腺素加压反应的影响。结果 :口服胆酸组的动脉血压及离体肠系膜动脉对去甲肾上腺素的加压反应较对照组均明显升高 (P <0 .0 1) ;口服甘草甜素组的动脉血压及离体肠系膜动脉对去甲肾上腺素的加压反应较对照组也明显升高 (P <0 .0 1)。结论 :胆酸和甘草甜素通过增加动脉对儿茶酚胺的反应性致血压升高。
Objective:To observe the action of cholic acid and glycyrrhizin on blood pressure and the peripheral vascular response to pressor agonists. Methods:We divided 34 male Wistar rats into four groups: ①control group (n=7),②cholic acid -treated group 1(80mg/kg/d 1weeks n=11), ③ cholic acid -treated group 2(80mg/kg/d 5 weeks n=7),④ glycyrrhizin-treated group (200mg/kg/d 6 weeks n=9).The blood pressure was monitored by means of pressure transducer connected to a ploygraph. Mesenteric arterial perfusion ex vivo was performed. Norepinephrine (0.5ug, 1.0ug, 2.0ug in 100ul respectively) were administered by bolus injection. The highest perfusion pressure for mesenteric arteries were constantly monitored by ploygraph.Results: The blood pressure was higher in the rats treated by cholic acid or glycyrrhizin than in those of the control group ( P <0.01).The perfusion pressure for mesenteric arteries in rats treated by cholic acid or glycyrrhizin after a bolus injection of norepinephrine showed a significant increase compared to the normal animals ( P <0.01). Conclusions:Cholic acid and glycyrrhizin may result in hypertension by influencing peripheral vascular response to pressor agonist.
出处
《中国现代医学杂志》
CAS
CSCD
2002年第12期48-50,共3页
China Journal of Modern Medicine
关键词
动脉血压
胆酸
甘草甜素
血管反应
高血压
Arterial Blood Pressure
Cholic Acid
Glycyrrhizin Vascular Reactivity
