摘要
目的 :观察和评价还原型谷胱甘肽减轻以大剂量顺铂为主的联合化疗所导致的肾毒性。方法 :对病理证实的晚期非小细胞肺癌27例、消化道癌39例及卵巢癌19例应用含顺铂为主的联合方案化疗 ,其中顺铂剂量70～80mg1～3天 (总量150mg～240mg) ,同时给予还原型谷胱甘肽1.5g/m2,静脉注射 ,第1～5天。结果 :以顺铂为主的联合化疗有效率均达到50 %以上 ,而化疗前后患者血肌酐清除率、尿素氮、尿蛋白及电解质均未出现异常。结论 :还原型谷胱甘肽可有效保护肾功能 ,临床应用可预防大剂量顺铂化疗所导致的肾毒性并减少水化和碱化 ,有利于临床应用。
Objective: To observe and evaluate the efficacy of glulathione in the treament of renal toxicity caused by cisplatin based chemotherapy.Methods: All the advanced malignancy cases were proved by pathology including None small cell lung cancer(27 cases),digestive cancer (39cases)and ovary carcinoma (19cases).The patients received combination chemotherapy based on high dose cisplatin.The dose of cisplatin was 70～80mg,d1～d3.(total 150mg～240mg).At the same time,glutathione was offered from d1-d3.The dose was 1.5g/m2 ,d1～d5 .Results : The response rate of combination chemotherapy with high dose cisplatin was over 50%,and the values of great,Bun,u-protein and electrolytes were normal .Conclusion: Glutathione has good protection on renal function.It can reduce the application of chemotherapy based on high dose cisplatin.
出处
《天津医科大学学报》
2002年第2期225-226,229,共3页
Journal of Tianjin Medical University
关键词
还原型谷胱甘肽
大剂量顺铂
肾毒性
预防
Glutathione(GSH)
High-dose cisplatin
Renal toxicity
Protection
