摘要
目的 探讨孕妇血清标记物甲胎蛋白 (AFP)和游离绒毛膜促性腺激素 (F - βHCG)对孕中期孕妇进行唐氏综合征为主的先天缺陷筛查的作用。方法 对孕中期 (14～ 2 0 6 W)妇女进行上述二项血清生化指标检测 ,经过软件计算风险 ,对可能影响检测结果的部分因素 ,如孕妇年龄、体重、孕周等加以分析校正 ,对高风险孕妇 ,进一步行羊水或脐血染色体检查及B超进行确诊。每例受检的孕妇随访追踪到出生。结果 871例孕妇中 ,发现唐氏综合征 2例 ,X -三体综合征 1例 ,平衡易位携带者 3例 ,其它胎儿异常 6例。结论 孕中期血清AFP、F -βHCG二项血清生化指标联合检测 ,作为筛查胎儿先天缺陷 ,尤其是胎儿染色体三体征及表皮缺陷、畸形有效可行。筛查结果高危孕妇应进一步行羊水染色体或B超检查确诊 。
Objective To investigate the value of detecting plasma α-fetoprotein(AFP) and free-β human chorionic gonadotropin (F-βHCG) at midtrimester pregnance in screening congenital defects chiefly for Doun Syndrome.Methods Assess the risk by software through the two blood biochemical tests at 14 to 20 gestational week' s plus 6 days. Analysis and revise partly factors which may affect the results such as the age,body weight and gastational weeks of the pregnant women. Next ancillary investigations were selected in the appropriate cases, included amnionic fluid chromosome, umbilical blood chromosome test or ultrasonic examination, if there was a high risk of congenital defect. The pregnant outcomes were followed up.Results There were 2 cases of Down Syndrome, one case of trisomy X syndrome, 3 cases of balance translocation carrier and 6 cases of other abnormalities among the 871 cases.Conclusions Coexamination of serum AFP and F-βHCG as method to screen fetal congenital defect,especially in fetal trisomy syndrome and cortex imcomplete malformation is feasible. Amnionic fluid chromsome test or ultrasonic examination is useful to diagnose further, and could reduce the birth of deficient neonatal for high suspicions case.
出处
《中国医师杂志》
CAS
2002年第6期635-637,共3页
Journal of Chinese Physician
关键词
唐氏综合征
甲胎蛋白
绒毛膜促性腺激素
产前筛查
产前诊断
Down Syndrome
α-Fetoprotein
Human chorionic gonadotropin (HCG)
Prenatal screen
Prenatal diagnosis
