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以质粒为载体的基因治疗现状 被引量：4

The Situation of Plasmid Vector in Gene Therapy
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摘要 近年来,质粒载体在基因治疗中的应用已引起人们的关注,并取得了很大进展。与病毒载体相比,质粒的优点为:制备简单,快捷,成本低廉,用于基因治疗较安全,并能与其它合成载体联合使用。本文就近年来质粒载体的发展,对质粒的设计,质粒导入机体的方法和途径、体内分布,和质粒抗癌药物的疗效进行了综述。
作者 孙丽 刘定干
机构地区 中科院上海生物化学和细胞生物学研究所
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 2002年第2期137-139,共3页 Chinese Journal of Cancer Biotherapy
基金 中国科学院上海生命科学研究院创新工程研究基金资助
关键词 基因治疗 质粒载体 阳离子脂质体 肿瘤
分类号 R730.54 [医药卫生—肿瘤] Q782 [生物学—分子生物学]
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参考文献16

  • 1[1]Mulligan RC. The basic science of gene therapy [ J ]. Science,1993, 260: 926-932.
  • 2[2]Lew D, Parker SE, Latimer T, et al. Cancer gene therapy using plasmid DNA: Pharmacokimetic study of DNA following injection in mice (see abstract) [J]. Hum Gene Ther, 1995, 6: 553-564.
  • 3[3]Sakurai F, Nishioka T, Saito H, et al. Interaction between DNA cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous rout in mice: The role of the neutral helper lipid[J]. Gene Ther, 2001, 8: 677-686.
  • 4[4]Horton HM, Dorigo O, Hemandez P, et al. 1L-2 plasmid therapy of murine ovarian carcinoma inhibits the growth of tumor aseites and alters its eytokine profile[J]. J Immunol, 1999, 281: 78-81.
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同被引文献17

  • 1罗心静,徐克前.血清乙肝病毒DNA的快速提取及定量PCR测定中应用的探讨[J].中国现代医学杂志,2004,14(18):124-126. 被引量：3
  • 2Schabitz WR,Hoffmann TT,Heiland S,et al.Delayed neuroprotective effect of insulin-like factor-1 after experimental transient focal cerebral ischemin monitored with MRI[J].Stroke,2001,32(5):1226.
  • 3Bilak MM,Kunel RWNENG.Delayed application of IGF-1 and GDNF can rescue already injured postnatal motorneurons [J].Neuroreport,2001,12(11) :2531.
  • 4Su-Fen Pu,Hui-Xin Zhuang,Differential spatio-temporal expression of the insulin-like growth factor genes in regenerating sciatic nerve[J].Molecular Brain Reserch,1995,34:18.
  • 5Timing of Human Insulin-Like Growth Factor-1 Gene Transfer Reinnervating Laryngeal Muscle.The American Laryngological,Rhinological & Otological Society,Inc.2004,114(4) :726.
  • 6Zheng WH,Kar S,Dore S,et al.Insulin-like growth factor-1(IGF-1):a neuroprotective trophic factor acting via the Akt-kinase pathway[J].J Neural Transm Suppl,2000,60:261.
  • 7TAKAI T. Fc receptors and their role in immune regulation and autoimmunlty[J]. J Clin Immunol, 2005, 25(1): 1-18.
  • 8NIMMERJAHN F, RAVETCH JV. Fc γ receptors as regulators of immune responses[J]. Nat Rev Immunol, 2008, 8(1): 34-47.
  • 9LIM SH, VAUGHAN AT, ASHTON-KEY M, et al. Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy[J]. Blood, 2011, 118(9): 2530-2540.
  • 10MCGAHA TL, KARLSSON MC, RAVETCH JV. Fc γRIIB deft- eieney leads to autolmmunity and a defective response to apopto- sis in Mrl-MpJ mice[J]. J Immunol, 2008, 180(8): 5670-5679.

引证文献4

二级引证文献5

中国肿瘤生物治疗杂志
2002年 第2期

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