摘要
目的 :通过本项实验 ,测算出 ip马蔺子素的表观药动学参数 ,为该药的注射应用提供参考。方法 :小白鼠6 0只分为 6组 ,各组间隔不同时间 (0 .5～ 16 h) ,两次 ip马蔺子素 L D50 ,由各组死亡率按公式求出首次用药后不同时间的体存量并作图。结果 :药代动力学参数 :K2 1 =0 .86 5 9/ h,K1 0 =0 .2 0 2 4 / h,K1 2 =0 .2 716 / h,Vc=1.395 7kg/ kg,Vp=8.5 4 4 7kg/ kg,Vt=9.94 0 4 kg/ kg,VB=1.92 3kg/ kg,AUC=70 .796 5 m g/ kg· h- 1 ,Cl=0 .2 82 5 kg/ h。结论 :马蔺子素 ip给药途径的表观药动学参数 ,大致与 ig给药途径相似 ,因此采取注射给药是可行的 ,且剂量还可大大降低。
Objective: The essay of the pharmacokinetic of tectpquinone(ip) will provide possible evidence for its injection application. Methods: 60 mice were divided in to six group, at various time intervals (0.5 16h), twice injected (i.p.) tectoquinone from LD 50 and according to the equation to calculate pharmacokinetics parameters. Results: The pharmacokinetics parameters of tectoquinone(ip): K 21 =0.865 9/h, K 10 =0.202 4/h, K 12 =0.271 6/h, Vc= 1 395 7 kg/kg, Vp=8.544 7 kg/kg, Vt=9.940 4 kg/kg, V B=1.923 kg/kg, AUC=70.796 5 mg/kg·h -1 , Cl=0.282 5 kg/h. Conclusion: The essay of the pharmacokinetics of tectoquinone(i.p.) basically are similar with its ig. administration, so that it may be practical for injection administration and the dosage can be largely decreased.
出处
《天津药学》
2002年第3期36-37,共2页
Tianjin Pharmacy
