摘要
目的 了解血管紧张素转换酶抑制剂 (ACEI)首剂应用时的低血压反应。方法 观察 4 0例慢性心力衰竭患者 ,其中培哚普利 (Perindopril)组首剂服 2mg、苯那普利(Benazepril)组 2 5mg、依那普利 (Enalapril)组 2 5mg及对照组 ,测基础及首剂服药后 0 5h、1h、2h、3h、4h、5h、6h的血压。结果 各组收缩压最大下降值 ,培哚普利为 6 0± 2 0mmHg。苯那普利为 5 8± 3 2mmHg。依那普利为 6 1± 4 0mmHg ,对照组为 (3 5± 3 8)mmHg ,各ACEI组均有血压下降 ,但组间无显著性差异 ,未见症状性低血压反应。结论 慢性心力衰竭首剂ACEI时虽有血压下降 ,但未见有首剂综合征的临床表现 ,故初步认为ACEI首剂应用于慢性心力衰竭是安全的。
Objectives To study angiotensin converting enzyme inhibitors (ACEI) produce first dose hypotension response in chronic heart failure (CHF) Methods 40 patients were divided in Perindopril 2 mg,Benazepril 2 5 mg,Enalapril 2 5 mg and control groups,blood pressures of each patient were measured at baseline,0 5 h?1 h?2 h?3 h?4 h? 5 h ?6 h after first dose of ACEI,respectively Results The each ACEI caused a small fall of systolic blood pressure over observation period,but there were no significant differences before and after treatment in each ACEI group,and no clinical symptoms of hypotension appeared after first dose ACEI Conclusions The first dose ACEI could decrease blood pressure,but did not cause first dose syndrome of ACEI,so,it seems to be safe in therapy of patients with CHF.
出处
《岭南心血管病杂志》
2002年第3期202-203,共2页
South China Journal of Cardiovascular Diseases
