摘要
本文介绍几种治疗糖尿病药物的最新进展。（1）新一代磺酰脲类药物格列美脲 该药作用于胰岛素分泌的第一、二时相,作用可持续1d,服用方便,1次/d。由于与其他磺酰脲类作用的受体亚型不同,格列美脲不易产生低血糖,且对心血管系统影响较小。（2）胰岛素促分泌剂 作用特点为起效快,作用时间短,能重塑胰岛素分泌模式,餐时服用十分方便。（3）胰岛素增敏剂噻唑烷二酮类 为过氧化物酶体增殖体激活受体γ高度选择性及强力激活剂,该药直接针对2型糖尿病发病机制——胰岛素抵抗。（4）其他新型降糖药。
In recent years,novel medicines treating diabetes have been exploited rapidly. As a result of further research on the physiology of β cell and insulin peripheric action, new drugs for diabetes are applied in clinic one after the other. This article introduces several latest medicines treating diabetes. (1) New generation of sulfaurea drugs glimepiride. This medicine acts on the first and second phases of insulin secretion and its action lasts 24 hours. Because of different receptor subtype coupled with, it seldom leads to hypoglycemia and has less affect on cardiovascular system either. (2) Insulin secretagogue. This kind of drugs quickly starts its effect, but its action maintains a short time. They can reshape the model of insulinsecretion. (3) Insulin synergist-TZDs. They are the highly selected and potent agonists of peroxisome proliferator-activated receptor-γ. Their action directly point at insulin resistance. (4) Other anti-hyperglycemic drugs.
出处
《药学服务与研究》
CAS
CSCD
2002年第2期69-72,共4页
Pharmaceutical Care and Research
