摘要
目的 :评价血清游离绒毛膜促性腺激素α亚单位 (Fαh CG)作为预测妊娠高血压综合征 (妊高征 )的价值。方法 :用单克隆放射免疫试剂测定 74例孕 2 1～ 4 3周妊高征患者血清 ,并与 37例孕周匹配的非妊高征者血清作对照 ,采用受试者工作曲线最大 Youden指数确定最佳阈值。结果 :妊高征组 Fαh CG水平显著高于对照组 [(5 5 6±4 2 8) IU/ L vs2 32± 131) IU/ L],(t=5 .6 6 ,P<0 .0 0 1) ;Fαh CG取值 2 6 0 IU/ L作为预测妊高征的阈值 ,其敏感性为81.1% ,特异性为 75 .7% ,Youden指数为 0 .5 7。结论 :Fαh CG可作为预测妊高征的血清标志物 ,取值 2 6 0 IU/ L可作为最佳阈值。
Objective: To evaluate the free alpha subunit of human chorionic gonadotropin (FαhCG) as a marker for pregnancy induced hypertension (PIH). Methods: The study group consisted of 74 pregnant women with hypertension. PIH admitted at 21 43 weeks of gestation. The control group was 37 non PIH women. Serum FαhCG was measured by radioimmunoassay with monoclonal technology. Using Youden's index of the receiver operator characteristic curve (ROC), a threshold value was determined. Results: FαhCG levels in PIH women were significantly higher than in the control group women [(556±428)IU/L vs (232±131)IU/L, P <0.001].Using 260 IU/L of FαhCG as the threshold value yields a sensitivity of 81.1% and specificity of 75.7% with a Youden's index of 0.57 for predicting PIH. Conclusion: Serum FαhCG may serve as a useful marker to predict PIH.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2002年第3期210-211,218,共3页
Journal of Zhejiang University(Medical Sciences)
