摘要
目的 探讨白细胞介素 13(IL 13)在抑制脑卒中炎性损伤中的作用。方法 用酶联免疫吸附法 (ELISA)测定 5 0例脑梗死患者及 30例脑出血患者发病后 48h内及第 6～ 8天、第 15天血浆IL 13的水平 ,并检测 6 0例对照者的血浆IL 13水平。结果 脑梗死组 3个时相血浆IL 13水平 (ng/L)分别为 37 6± 6 2 ,45 2± 10 1,41 3± 8 3;脑出血组为 36 6± 4 9,45 3± 8 9,38 1± 5 6 ;均较危险因素对照组 (2 8 0± 3 2 )及健康对照组 (2 6 4± 2 7)明显增高。中度 (脑梗死组 :40 7± 5 8,5 1 1± 8 0 ,44 8± 7 2 ;脑出血组 :38 2± 4 1,48 2± 5 8,38 7± 4 1)及重度 (脑梗死组 :42 3± 5 2 ,5 3 3± 7 2 ,47 3± 9 6 ;脑出血组 :38 6± 3 9,5 2 2± 9 2 ,40 6± 7 6 )患者血浆IL 13水平明显增高 ,且第 6～ 8天的水平最高。结论 IL 13可能参与了抑制脑卒中炎性损伤的病理过程 ,并与病情程度呈正相关。
Objective To study the changes of plasma interleukin-13 (IL-13) in patients with acute cerebral stroke and its effects in the cerebral inflammatory reactions. Methods The levels of plasma IL-13 measured in 50 patients with acute cerebral infarction (CI group) and in 30 patients with cerebral hemorrhage (CH group) using enzyme-linked immunoabsordent assay(ELISA) were compared to the control A (with the risk factors of stroke) and control B (normal group).Results As compared with the controls (control A: 28.0±3.2; control B: 26.4±2.7), the levels of plasma IL-13(pg/ml) were increased in three periods in the CI group (37.6±6.2;45.2±10.1;41.3±8.3) and CH group (36.6±4.9;45.3±8.9,38.1±5.6) ( P <0.01), showing a higher level in medium (CI group: 40.7±5.8, 51.1±8.0,44.8±7.2;CH group: 38.2±4.1, 48.2±5.8, 38.7±4.1) and in severe (CI group: 42.3±5.2, 53.3±7.2,47.3±9.6; CH group: 38.6±3.9,52.2±9.2,40.8±7.6) patients.Conclusion IL-13 may play a down-regulation role in the inflammatory reactions of the acute cerebral stroke.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2002年第3期151-153,共3页
Chinese Journal of Neurology
