摘要
目的:观察降脂减肥茶的长期毒性。方法:降脂减肥茶高、中、低剂量组按7g/kg、3.2g/kg、1.5g/kg给SD大鼠灌胃,分别相当于临床用量的100倍、50倍、20倍。给药6周、12周和停药3周后,观察大鼠的行为活动、食欲、二便、体重、血液学和血液生化学指标,以及主要脏器系数和病理组织学检查。结果:3个给药组分别与对照组比较,各项指标差异无显著性意义。结论:本品在临床推荐的用药剂量下有一定的安全性。
Objective: To investigate the chronic toxicity of tea for descending lipid and declining fat (TDLDF). Methods: 4 groups Sprague-Dawley rats had respectively been fed with distilled water and TDLDF in 7 g/kg (high dosage), 3.2 g/kg (middle dosage) and 1.5 g/kg(lower dosage) for 12 weeks, the latter were respectively equal to 100, 50 and 20 times clinical dosage. After ig 6, 12 weeks and 3 weeks after discontinuation, the behavior, appetite, excrement and urine, body weight, hematological and biochemical markers, coefficient of the main organs and pathohistological examinination of the rats were investigated. Result: There were no significant differences of the above markers between each experimental group and the control group. Conclusion: The clinical recommended dosage of TDLDF is safe.
出处
《中药材》
CAS
CSCD
北大核心
2002年第6期423-425,共3页
Journal of Chinese Medicinal Materials
基金
广东省中医药管理局资助课题(98437)
关键词
降脂减肥
长期毒性
毒理学
实验研究
Tea for descending lipid and declining fat
Long-term Toxicity
Toxicology
