摘要
目的 探讨三磷酸腺苷介入心肌灌注断层显像 (ATP MPI)诊断冠心病 (CAD)的临床价值。方法 ATP MPI 2 78例 ,其中 5 1例行冠状动脉造影 (CAG) ,并与运动心肌灌注断层显像 (ST MPI,73例 ,均行CAG)对照。结果 ①不良反应 :有 11种不适症状 (发生率 1.4%～ 2 4.5 % ) ;Ⅰ～Ⅱ度Ⅱ型房室传导阻滞和Ⅱ度Ⅱ型窦房传导阻滞各 10例和 2例。所有患者均未中途停药 ,仅作对症处理。②ATP MPI诊断CAD的灵敏度和特异性分别为 97.1%和 82 .4% ,探查冠状动脉血管狭窄的灵敏度和特异性分别为 91.0 %和 94.7%。③对非心肌梗死患者 ,ATP MPI诊断心肌缺血的灵敏度和特异性与ST MPI相比差异无显著性。结论 ATP MPI诊断CAD的准确性较高 ,诊断价值与ST MPI相同 ;安全性好 ,尤其适合无法运动和高血压患者。
Objective To study the clinical value of adenosine triphosphate stress myocardial perfusion tomography imaging (ATP-MPI) in detection of coronary artery disease (CAD). Methods There were 278 patients underwent ATP-MPI, 51 patients of them also underwent coronary angiography (CAG). Seventy-three patients underwent stress-rest myocardial perfusion tomography imaging with multi-stage submaximal exercise test (ST-MPI) and CAG serving as control group. Results ①Side effects: there were 11 different symptoms and atrioventricular conduction block (10 patients), sinoatrial conduction block (2 patients) occurred during ATP stress. Allopathy or interruption of ATP stress did not happen. ②The sensitivity and specificity of ATP-MPI in detection of CAD were 97.1% and 82.4%, respectively, and those in detection of ≥50% narrowing coronary artery were 91.0% and 94.7%, respectively. ③In patients without myocardial infarction, the sensitivity and specificity of ATP-MPI in detection of myocardial ischemia were comparable to those of ST-MPI. Conclusion ATP-MPI is an accurate, safe modality and is comparable to ST-MPI in the detection of CAD.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2002年第3期159-161,共3页
Chinese Journal of Nuclear Medicine
基金
国家卫生部保健局保健科研基金资助项目 ( 0 0 3)
关键词
ATP介入
心肌灌注断层显像
诊断
冠心病
临床价值
Coronary disease
Adenosine triphosphate
Tomography, emission-computed, single-photon
