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基因芯片在筛选卵巢癌基因中的应用研究 被引量：1

The study on gene expression patterns in ovarian carcinomas by cDNA microarrays.
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摘要 目的:研究人卵巢癌相关基因在卵巢癌组织和正常卵巢组织中的差异表达。方法:用含512条癌及抑癌基因的cDNA表达谱芯片研究一组卵巢癌组织样本的基因表达谱。结果:共筛选出差异表达与癌相关的基因54条,其中18条表达上调,36条表达下调。结论:用基因表达谱芯片研究基因谱,可有效的筛选出新的卵巢癌相关基因。 ve:To compare the differential expression gene between ovarian cancer and normal ovary tissue using cDNA microarrays. Methods: Analysis of human ovarian cancer expression microarrays was initiated by cDNA microarrays with set of 512 human genes.Results: 54 genes ex-pressed in ovarian cancer were screened out. Among them, 18 were up-regulated and 36 were down-regulated. Conclusions: cDNA microarray technique is effective in screening the differentially ex-pressed genes between different tissues. Further analysis of those obtained genes will be helpful to understand the molecular mechanism of malignant tumor.
作者 昌晓红 崔 恒 冯 捷
机构地区 北京大学人民医院妇科肿瘤中心
出处 《现代妇产科进展》 CSCD 2002年第3期175-178,共4页 Progress in Obstetrics and Gynecology
关键词 基因芯片 基因表达谱 卵巢肿瘤 基因 差异表达 Gene chips Gene expression pattern Ovarian neoplasms Gene, differential ex-pression
分类号 R737.31 [医药卫生—肿瘤]
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参考文献10

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同被引文献13

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现代妇产科进展
2002年 第3期

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