摘要
卡西霉素(A_(23187))刺激大鼠腹腔巨噬细胞释放血小板活化因子(PAF),用洗涤血小板聚集的方法测定,证明商陆皂甙甲在0.1～100μmol/L浓度范围内及所试的时间范围内,呈剂量及时间依赖性抑制大鼠腹腔巨噬细胞释放PAF:商陆皂甙甲可能就是通过抑制体内PAF生成而起抗炎作用的。
Platelet activating factor (PAF)is a kind of inflammatory mediator. We used the method of aggregation of washed rabbit platelet to study the effect of esculentoside A (EsA) on the release of PAF from calcimycin (A_(23187)) stimulated rat peritoneal macrophages and found that the release of PAF was inhibited by EsA in a time and dose dependent manner. The IC_(50) of EsA for the inhibition of PAF release was 1.5μmol/L.Under the same condition, the release of PAF was also inhibited by mepacrine at 100 μmol/L. The results indicate that EsA is a potent inhibitor of PAF synthsis in rat peritoneal macrophages.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第10期721-724,共4页
Acta Pharmaceutica Sinica
关键词
商陆皂甙甲
血小板
卡西霉素
Esculentoside A (EsA)
Platelet activating factor (PAF)
Calcimycin (A_(3187))
Macrophage
