摘要
目的 :探讨 2型糖尿病患者胆结石与高胰岛素、脂代谢紊乱的关系。方法 :采用病例对照研究的方法 ,观察 5 0例伴胆结石与 6 0例不伴胆结石的 2型糖尿病患者血清胰岛素、胰岛素敏感指数、C肽、血脂的变化。结果 :发现伴胆结石患者的血清胰岛素、C肽、甘油三酯、胆固醇显著高于不伴胆结石组 (P <0 .0 5 ) ,高密度脂蛋白、胰岛素敏感指数显著低于不伴胆结石组 (P <0 .0 5 ) ,载脂蛋白 A1明显降低 (P <0 .0 1) ,而两组低密度脂蛋白、脂蛋白 a、载脂蛋白 B1无差异。结论 :高胰岛素血症、脂代谢异常可能是中老年 2型糖尿病患者胆结石形成的高危因素。
Objective:To study the correlation between cholelithiasis and hyperinsulinemia or dyslipoidosis in type 2 diabetes.Methods: A case-matched study was carried out to investigate the changes of insulin,insulin sensitivity index(ISI)cp, serum lipids in type 2 diabetic patients with cholelithiasis and without cholelithiasis. Result:fifty diabetics with cholelithiasis had higher triglyceride(TG), insulin, cp, and cholesterol(CH) ( P <0.05),lower hight density lipoprotein cholesterol(HDL-C),ISI ( P <0.05),Apo-A1( P <0.01) than sixty diabetics without cholelithasis.There are no significant differences in lowdensity lipoprotein cholesterol(LDL-C),Lpo-a,Apo-B1.Conclusions:The results indicate that highinsulinemia,dyslipoidosis might be a risk factor for the development of cholelithiasis in type 2 diabetic patients.
出处
《江苏大学学报（医学版）》
CAS
2002年第2期149-150,共2页
Journal of Jiangsu University：Medicine Edition
关键词
糖尿病
胰岛素
胆结石
血脂
Diabetes
Insulin
Cholelithiasis
Lipids
