摘要
本文从重症肝炎(SH)及慢性活动性肝炎(CAH)患者血清及外周血巨噬细胞(Mφ)着手探讨了其白细胞介素2(IL—2)活性低下的机制。发现SH和CAH患者血清及Mφ均能抑制SH,CAH患者及健康献血员的IL-2活性;进一步研究表明SH及CAH患者血清中存在着IL—2抑制因子,并对该抑制因子的物理性状作了初步研究。
The interleukin-2 (IL-2) activity of 23 cases of chronic active hepatitis (CAH) and 26 cases of severe hepatitis (SH) were investigated. The results indicated that: 1) There may be one more inhibitory factor (s) of large molecules existing in the blood of the patients, such factor (s) in partly destroyed at -20℃ or 56℃, it can adhere to the surface of PBMC or stimulate the surface receptor of, PBMC; 2) The function of Mφ for promoting the production of IL-2 in patients with SH and CAH is abnormal although quantitatively unaltered.
出处
《湖南医科大学学报》
CSCD
1989年第1期57-60,共4页
Bulletin of Hunan Medical University
关键词
肝炎
白细胞介素2
淋巴细胞
hepatitis, viral, human
hepatitis, chronic active
mitogenic factors,lymphocyte
