摘要
目的 :观察西咪替丁 (Cim)对血小板功能及血栓形成的影响。方法 :在体外 ,Cim与血小板温育后 ,测量血小板聚集、血小板生成丙二醛 (MDA)、血小板内游离钙 [Ca2 + ]i 及血栓素B2 (TXB2 )含量。用电刺激大鼠颈动脉诱导血栓形成并观察Cim的促进作用。结果 :Cim使ADP诱导的血小板聚集增加 ,凝血酶诱导的血小板 [Ca2 + ]i、MDA升高 ,TXB2 下降 ,使电刺激大鼠颈动脉闭塞时间 (OT)缩短。结论 :Cim增强血小板功能 ,促进血栓形成。
AIM: To observe the effects of cimetidine(Cim) on platelet function and thrombosis. METHODS: After incubated with Cim in vitro , rat platelets were activated with ADP or thrombin. The platelet aggregation, platelet malondialdehyde(MDA) formation, platelet intracellular free calcium([Ca 2+ ] i), and thromboxane B 2 (TXB 2) were measured. The effects of Cim on electric-induced thrombosis in rat carotid artery were examined. RESULTS: Cim potentiated ADP induced platelet aggregation , increased the thrombin induced [Ca 2+ ] i and MDA formation, decreased TXB 2. Also, Cim shortened the duration of electric-stimulated occlution time in rat carotid artery. CONCLUSION: Cim increased platelet function and accelerated thrombosis.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2002年第5期526-527,共2页
Chinese Journal of Pathophysiology
