摘要
ADAM ,又称MDC ,分别是去整合蛋白和金属蛋白水解酶 (adisintegrinandmetalloproteinase,ADAM)及金属蛋白水解酶、去整合蛋白和富半胱氨酸 (metalloproteinase/disintegrin/cysteine -rich ,MDC)的英文缩写 ,是近几年在多细胞动物中发现的一类含信号肽区、前调控区、金属蛋白水解酶区、去整合蛋白区、富半胱氨酸区、上皮生长因子区、跨膜区和胞内区的细胞表面糖蛋白 ,本文简要总结了有关ADAM起源、遗传、进化和亲缘关系的研究结果。
ADAM (a disintegrin and metalloproteinase),or named MDC (metalloproteinase/disintegrin/cysteine-rich) is a family of glycoproteins in cell surface,which was found in recent years and consists of a signal peptide,a propetide,a metalloproteinase,a disintegrin,a cysteine-rich domain,and an epidermal growth factor (EGF)-like domain,a transmembrane region,and a cytoplasmic tail.The research results about their origin,heredity,evolution and evolutionary relationship are summaried in this paper.
出处
《遗传》
CAS
CSCD
北大核心
2002年第3期367-370,共4页
Hereditas（Beijing)
基金
河南省生物工程重点实验室资助项目 (编号 :PKL0 10 0 5 )
关键词
ADAM
遗传
进化
种类
分化
亚当斯蛋白
蛇毒金属蛋白水解酶
基质金属蛋白水解酶
染色体定位
同源性比较
a disintegrin and metalloproteinase (ADAM)
snake venom metalloproteinases (SVMPs)
matrix metalloproteinases (MMPs)
gene
chromosome localization
heredity and evolution
homologous comparison
