摘要
目的 研究N -乙酰半胱氨酸 (NAC)对烟雾吸入性肺损伤氧化应激及抗氧化能力的影响。 方法 采用烟雾吸入性肺损伤大鼠模型 ,检测吸入伤后肺泡灌洗液 (BALF)中白细胞数(WBC)、肺组织髓过氧化物酶 (MPO)活性、过氧化氢 (H2 O2 )含量、谷胱甘肽 (GSH)含量及总抗氧化能力(TAO)。 结果 NAC治疗可显著降低吸入伤后BALF中WBC数 ,降低肺组织MPO活性及H2 O2 含量 ,并显著提高肺组织GSH含量及TAO水平。 结论 NAC治疗可减轻吸入伤后肺脏氧化应激程度 。
Objective To investigate the influence of N-acetyl-L-cysteine (NAC) on pulmonary injury and oxygen stress caused by smoke inhalation injury. Methods Rats inflicted with smoke inhalation injury were employed as the model.WBC in BALF(bronchoalveolar lavage fluid),MPO (myeloperoxidase) activity,hydrogen peroxide(H 2O 2) content,GSH(glutathione) content and total antioxidant (TAO) capacity in pulmonary tissue were determined. Results Postinjury WBC in BALF,MPO activity in pulmonary tissue and H 2O 2 content decreased obviously after NAC treatment.But the pulmonary tissue contents of GSH and ATO increased evidently after the treatment with NAC. Conclusion NAC treatment could ameliorate pulmonary oxygen stress after smoke inhalation injury.As a result,the pulmonary antioxidant capacity was improved.
出处
《中华烧伤杂志》
CAS
CSCD
2002年第3期151-154,共4页
Chinese Journal of Burns
