摘要
研究新生儿缺氧缺血性脑病（HIE）的甲状旁腺素（PTH）、降钙素（CT）及血钙水平变化,为临床治疗HIE提供参考依据。应用放射免疫法对59例足月HIE患儿（轻度组18例,中度组21例,重度组20例）,于急性期及恢复期各测定一次血清PTH、CT及钙水平,并以20例正常足月新生儿作为对照组。结果显示:轻、中、重度HIE组患儿急性期血钙水平分别为2.23±0.21、2.06±0.23、1.88±0.25,均低于对照组2.39±0.28（P值分别为<0.05、0.001、0.001）,且临床分度愈重,血钙下降愈明显,HIE各组间差异显著;中、重度HIE组PTH水平分别为210.356±56.142、201.461±62.763;CT水平分别为115.879±36.469、124.765±48.571,较对照组及轻度HIE组PTH降低、CT升高（P<0.05）。HIE各组患儿恢复期血钙复升,中、重度HIE组PTH复升、CT下降,与急性期比较有显著差异（P<0.05）,但重度HIE组恢复缓慢。结论:HIE时PTH下降、CT升高与血钙降低有关,在治疗HIE患儿时应严密监测血钙,应用钙剂应掌握适应症和剂量,极为重要。
In order to study the changes of serum parathormone(PTH), calcitonin(CT) and calcium in neo-nates with hypoxic-ischemic encephalopathy (HIE), the levels of PTH, CT and Ca(calcium) in the serum were measured by radioimmunoassay in 59 full term neonates with HIE (18 cases in mild degree, 21 cases in moderate degree, and 20 cases in severe degree). In acute stage and convalescent stage 20 normal full term neonates as control. Results In acute stage, the more severe the HIE was, the lower the serum calcinm levels were. (P <0.05, 0.001, 0.001. The infants with moderate and severe HIE had lower PTH and higher CT comparied with those of infant with mild HIE and those as controls. In convalescent stage, the levels of blood calcium, PTH increased and the levels of CT decreased ( P < 0.05),but they recovered slowly in infant with severe HIE. Therefore, there are relationship between PTH decreasing, CT increasing and blood calcium decreasing in infant with HIE, cailcium must be monitored carefully and with appropriate intervention.
出处
《新生儿科杂志》
CAS
2002年第3期103-105,共3页
The Journal of Neonatology
