摘要
本文探讨了人参皂甙免疫调节效应的神经内分泌通路。将微量人参皂甙(5×10^(-9)kg/侧)经慢性导管直接导入大鼠双侧海马后,其胸腺细胞ConA增殖反应增强,胸腺细胞自发掺入增加,腹腔巨噬细胞分泌IL-1增多,血清免疫复合物下降,提示人参皂甙可通过海马调整免疫功能。
With the help of intrahippocampal microinjection technique, the neuroend-ocrine mechanism of immune effect of ginsenosides ( GS ) was studied in rats. After the injection of GS into the 2 hippocampi ( EC ) directly by conduits at the dose of 50μg per day each side for 4 days, ConA induced proliferation and spontaneous proliferation activity of thymocytes were enhanced significantly as compared with control group. IL- 1 secretion of periteneal macrophages was also increased, and the amount of serum circulating immune complexes was decreased. These results suggest that GS can indirectly adjust immune functions via HC.
出处
《徐州医学院学报》
CAS
1991年第4期242-246,共5页
Acta Academiae Medicinae Xuzhou
关键词
人参皂甙
海马
免疫功能
ginsenosides
hippocampus
immunity lymphocyte proliferation
IL-1
intrahippocampal microinjection
