摘要
目的 了解泼尼松治疗格雷夫斯病合并甲状腺机能亢进性心房颤动的临床效果。方法患者分为传统抗甲状腺药物组 (10例 ,男 2例 ,女 8例 )和泼尼松治疗组 (14例 ,男 3例 ,女 11例 )。治疗方案 :传统抗甲状腺药物组采用他巴唑 15～ 30mg/d ,心得安 15～ 30mg/d ,而泼尼松治疗组药物为泼尼松 30mg/d ,他巴唑 15～ 30mg/d ,心得安 15～ 30mg/d。比较二组患者心房颤动转复效果。结果泼尼松治疗组 14例患者有 12例心律转复为窦性心律 ,平均转复时间为 3 8(3 8± 2 6 )个月 ,缓解率达86 %。而传统抗甲状腺药物组 10例患者有 4例心律转复 ,缓解率为 4 0 % ,平均转复时间 2 8(2 8±1 0 )个月 ,泼尼松治疗组的转复效果明显高于传统抗甲状腺药物组 (P <0 0 5 )。
Objective To investigate the clinical effect of prednisone on hyperthyroid atrial fibrillation associated with Graves disease (HAFGD). Methods Twenty four patients with hyperthyroid atrial fibrillation associated with Graves disease were divided into two groups: traditional antithyroid group (10 cases, with 2 males and 8 females, treated by methimazole 15～30 mg/d and propranolol 15～30 mg/d) and prednisone group (14 cases with 3 males and 11 females, treated by methimazole 15～30 mg/d, propranolol 15～30 mg/d, and prednisone 30 mg/d). The effects of these two remedies on reversion from atrial fibrillation to sinus rhythm were compared. Results The cardiac rhythm reverted to sinus rhythm in 12 out of the 14 cases in prednison group with a reversion rate of 86% and the mean reversion time of 3.8 months (range 3.8±2.6 months), and in 4 out of the 10 cases in traditional antithyroid remedy group with the mean reversion rate of 40% and mean reversion time of 2 8 months (range 2.8±1.0 months). The reversion rate was significantly higher in prednisone group than in the traditional remedy group ( P <0.05). Conclusion Treatment of prednisone is more beneficial to reversion of atrial fibrillation into sinus rhythm among patients with HARGD.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2002年第12期810-812,共3页
National Medical Journal of China
