摘要
将小鼠暴露于不同浓度的家用洗涤剂后,对肝ATP酶、谷胱甘肽转硫酶(GST)、总氧自由基清除能力(TOSC)和脑乙酰胆碱酯酶(AChE)进行测定.结果显示,4周龄的小鼠暴露于家用洗涤剂时,在4~12d时间里即可使AChE、GST、TOSC等生物标志物受到影响,但ATP酶活力改变不明显,这些生物标志物的改变证明了家用洗涤剂对小鼠的早期影响.
ATPase, glutathione-S-transferase(GST) and total oxyradical scavenging capacity (TOSC) in the liver of mouse and acetyl-cholinesterase (AChE) in the brain of mice were determined after the mouse exposed to domestic detergent of different concentration. The results showed that when 4-week mice was exposed to domestic detergent, biomarkers such as AChE、GST、TOSC were affected in 4~12days; but there was no obvious change with ATPase activity. The change of these biomarkers proved the early effects of domestic detergent on mouse.
出处
《中国环境科学》
EI
CAS
CSSCI
CSCD
北大核心
2002年第3期254-257,共4页
China Environmental Science
基金
国家自然科学基金资助项目(39870157)
浙江省分析测试基金资助项目(00157)
关键词
多项生物标志物
评价
家用洗涤剂
小鼠
早期影响
ATPase
acetyl-Cholinesterase (AChE)
glutathione-S-transferae (GST)
total oxyradical scavenging capacity (TOSC)
domestic detergent
mouse
