摘要
目的 :观察盖诺 (NVB)、卡铂 (CBP)、异环磷酰胺 (IFO)、平阳霉素 (BLM A5 )、强的松 (PDN)组成的NCIBP方案治疗复发性非霍奇金淋巴瘤的近期疗效和毒副反应。方法 :采用NVB40mgivD1,8;CBP0 3ivd1;IFO1 0ivd1-3 Mesna0 4iv于IFO后 0、4、8小时各一次 ,d1-3 ;BLM A5 8mgimBiw× 2。结果 :全组 2 5例 ,CR16例 ,PR4例 ,总有效率 80 %。毒副反应主要是白细胞、血小板下降 ,发生率分别为 84%和 6 0 %,脱发发生率为 96 %。结论 :NCIBP方案治疗复发性非霍奇金淋巴瘤疗效较为满意。
Objective:To observe the efficacy and toxicity of NCIBP combination regime in the treatment of recurrent non-Hodgkins lymphoma using Vinorelbine,Carboplatin,Ifosfamide,Pingyangmycin and Prednisone.Methods:40 mg/m 2 NVB was infused by push on d 1.8;0.3 g CBP iv by drop on d 1;1.0 g IFO iv by drop on day 1-3;0.4 g Mesna iv by drop 0,4,8 hrs after infusion of IFO on d 1-3;8 mg PYM im Biw ×2 with 5 mg DXM before;30 mg PDN orally d 1-14.Every four weeks as one cycle.Assessment was given after two or three cycles.Results:The total response rate in 25 patients was 16/25(80%) with 16 CR and 4 RR.Major toxicity were neutropenia and thrombocytopenia with occurrence rate 84% and 60%,Ⅲ to Ⅳ grade neutropenia are 20%(5/25).Conclusion:NCIBP regime has significant efficiency in the treatment of recurrent non-Hodgkin's lymphoma and worth further clinical study.
出处
《临床肿瘤学杂志》
CAS
2002年第3期224-225,共2页
Chinese Clinical Oncology
关键词
盖诺
复发性
非霍奇金淋巴瘤
临床观察
化学疗法
Combination Chemotherapy
Recurrent non-Hodgkin's lymphoma
Short-term response
