摘要
现已公认神经系统钙通道参与伤害性信息的传导,其阻滞剂的镇痛效应也已被证实。特别是选择性强并具有可逆性的N-型电压敏感型钙通道阻滞剂———ziconotide,其蛛网膜下腔注射能产生良好的镇痛作用,长期应用也不出现耐受,现已被美国FDA批准可用于慢性疼痛治疗。
It is generally accepted that neuron al calcium channel is involved in the nociceptive pathway.The analgesic effects of calcium channel blockers have been testifie d.Ziconotide is a selective potent a nd reversible blocker of N-type volt age-sensitive calcium channel.It produces an apparent analgesic effe ct but does not produce tolerance aft er prolonged use.Intrathecal zicon otide has been recommend for ap-proval by the FDA for the management o f chronic pain.
出处
《中国临床康复》
CSCD
2002年第12期1712-1713,共2页
Chinese Journal of Clinical Rehabilitation
