摘要
目的 调查浙江地区胃癌病人胃组织中EB病毒的感染情况。方法 用PCR方法对26例胃癌组织和15例非胃癌胃组织标本进行EBV -DNA测定。 结果 26例胃癌病人胃癌组织EBV -DNA阳性19例 (73.1 % ) ;其中9例分化型腺癌EBV -DNA阳性5(55.6 % ) ,12例低分化腺癌阳性11例 (91.7 % ) ;5例粘液、印戒细胞癌阳性3例 (60 % )。对照组15例胃组织阳性6例 (40% ) ,( χ2=4.37,p<0.05)。结论 本研究提示 ,浙江地区胃癌病人胃癌组织存在较高的EB病毒感染 。
Objective To investigate Epstein-Barr virus(EBV)infection of gastric carcinoma(GC) in Zhejiang province Methods Detected EBV-DNA in 26 GC histiocyte and 15 benign gastric tissues with polymerase chain reaction(PCR). Results Of all the 26 cases with GC, the positive rate of EBV-DNA was 71.3% (19/26), in cases of well-moderately differentiated adenocarcinoma the positive rate was 55.6%(5/9), in cases of poorly differentiated was 91.7%(11/12), and in cases of mucious carcinoma was 60%(3/5). While in the cases of benign gastric disease the positive rate of EBV-DNA was 40%(6/15).The difference between the two groups was significant(p<0.05). Conclusions The GC tissue have high EBV infection in Zhejiang area, EBV may be involved in the occurrence and evolution of GC.
出处
《浙江临床医学》
2002年第6期409-410,共2页
Zhejiang Clinical Medical Journal
关键词
浙江
胃癌
EB病毒
聚合酶链反应
影响因素
Gastric carcinoma, Epstein-virus, Polymerase Chain reaction (PCR)
