摘要
目的 :探讨糖尿病肾病患者血液高凝状态与蛋白尿的关系。方法 :5 7例糖尿病肾病患者 ,以 2 4h尿蛋白定量分为高 (H)、中 (M )和低 (L)三组。并对其中 17例实施 8个月的华法令治疗。系统检测凝血、纤溶及肾功能指标。结果 :伴随尿蛋白量增多 ,凝血活性进一步亢进 ;但华法令改善高凝状态后 ,尿蛋白并无改善。结论 :血液高凝状态伴随糖尿病肾病患者蛋白尿出现而形成 ,并因此逐渐加重。
Objective:To investigate the relationship of hypercoagulation and proteinuria in patients with diabetic nephropathy(DN).Methods:Fifty-seven patients definitely diagnosed as diabetes type Ⅱ, DN participated in the study. According to 24 h urinary protein, they were divided into 3 groups including 16 cases as L group, 17 cases as M group; 24 cases as H group. 17 cases of 57 patients were received warfarin therapy. Detecting the parameter of coagulation and fibrolysis with ELISA as well as urinary protein and renal function.Results:Patients with major urinary protein (H group) appeared more activities of coagulation than that with moderate and mild renal dysfunction (L group and M group). Warfarin could obviously improve the state of hypercoagulation, but did not decreased urinaru protein in patients with DN.Conclusion:The proteinuria not only results in hypercoagulation,but also aggravates the hypercoagulable state in patients with DN.
出处
《中国中西医结合肾病杂志》
2002年第6期326-328,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
