摘要
以乙酸乙烯酯为原料,经氯化、水解与硫脲环合反应制备2-氨基噻唑,收率91％。将其在硫酸体系中,经成盐-硝化“一锅法”合成2-氨基-5-硝基噻唑。当反应物n（2-氨基噻唑）:n（硫酸）:n（硝酸）=1∶4∶1.05,30℃反应4小时,硝化产物收率为81％。
2-Aminothiazole has been prepared by chlorination, hydrolysis, then cyclized with thiocarbamide,vinylacetate being used as a starting material,iitheiiyield was 91%. 2-Amino-5-nitrothiazole was synthesized in one-pot reaction by sulfation and nitration of 2-aminothiazole in sulfuric and nitric acids. The yield of iinitration was 81% if a molar ratio of 2-aminothiazole to sulfuric acid and to nitric acid was 1: 4: 1.05 at 3℃ for 4hrs.
出处
《染料工业》
2002年第3期26-27,共2页
Dyestuff Industry
