摘要
目的 :观察小剂量尿激酶 (UK)与肝素和阿斯匹林联合治疗不稳定心绞痛 (U A)的临床疗效。方法 :采用单盲、随机方法。U K组按 u K2 5万 IU于 12 0 m in内静脉滴入 ,连续用 5 d。结果 :30 d的心脏死亡率两组间无显著性差异 (3.3%与 2 .9%,P>0 .0 5 ) ;急性心肌梗死 (AMI)发生率小剂量 U K组低于对照组 (3.3%与 19.6 %,P<0 .0 5 ) ,减少频发心绞痛发生率。小剂量 UK组明显优于对照组 (第 1周 :2 0 %与 47.1%,P<0 .0 1;第 4周 :6 .7%与 2 5 %,P<0 .0 5 )。结论 :小剂量 UK与肝素和阿司匹林联合应用治疗发病急重的 U A可明显降低 AMI和心绞痛的发生率。
Objective:To observe the clinical effect of low-dose urokinase (UK) in combination with heparin and aspirin in unstable anging(UA).Methods:This study was a multicenter,single-blind,placebo-controlled randomied clinical trial.In low-dose UK group,low-dose UK 250000 IU was given every two hours for 5 consecutive days.Results:There was no statistically significant difference in cardiac events between two groups(3.3 % vs 2.9 %,P>0.05),the tate of AMI was much lower in low-dose UK group than placebo group,the differences was significant (3.3 % vs 19.5 %,P<0.05).The number of patients with frequent anging was significant (3.3 % vs 19.5 % P<0.05).The number of patients with frequent angina was significant decrease in patients treat with low-dose UK as compared with patients in placebo,the differenas were also significant (first week:20 % vs 47.1 %,P<0.01;4th week:6.7 % vs 25 %,P<0.05) Conclusion:The risk of AMI and the number of patients with frequant angina might be remarkably reduced by using low-dose UK in combination with enoxaparin and aspirin.
出处
《山西临床医药》
2002年第5期337-338,共2页
Shanxi Clinical Medicine
