摘要
人体骨组织的多孔结构 ,有利于骨组织生长代谢所需物质的交流 ,并能很好地适应外部应力的变化。合成模拟骨组织多孔结构的生物活性陶瓷材料 ,用于临床人体骨组织缺失的修复 ,是组织工程所需要的。将化学沉淀法合成的羟基磷灰石原始粉末与过氧化氢、聚乙烯醇、甲基纤维素等成孔物质混合 ,经低温发泡 ,中温脱碳 ,高温烧结 ,可以获得孔径理想 ,互通性能良好的多孔羟基磷灰石陶瓷。这种陶瓷 ,在一定程度上具有骨诱导性能 ,但更重要的是它能够很好的吸附人体骨形成蛋白等骨生长因子 ,使其具有良好的骨再生能力 ,从而获得了良好的临床应用性能。本文从临床应用性能的角度 。
The macroporous structure of human bone allows the ingrowth of the soft tissues and organic cells into the bone matrix, profits the development and metabolism of bone tissue, and adapts the bone to the change of load. There is great requirement for artificial biomimic porous bioactive ceramics with the similar structure of bone tissue that can be used clinically for repairing lost bone. Fine hydroxyapatite (HAp) powder produced by wet chemical reaction was mixed with hydrogen peroxide (H 2O 2), polyvinyl alcohol, methyl cellulose or other pores making materials to form green cake. After drying at low temperature (below 100 ℃) and decarbonizing at about 300℃～400 ℃, the spongy ceramic block was sintered at high temperature, thus, macroporous HAp bioceramic with interconnected pores and reasonable porosity and pore diameter was manufactured. This kind of porous HAp bioceramics were intrinsically osteoinductive to a certain degree, but its outstanding property was that they can absorb human bone morphogenetic proteins and other bone growth factors to form composites, so that the macroporous HAp bioactive ceramic has appropriate feasibility for clinical application. From the point of biomedical application, the recent developments in synthesis and characteristics investigation of macroporous HAp are reviewed in this paper.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
2002年第2期302-305,共4页
Journal of Biomedical Engineering
基金
陕西省自然科学基础研究计划 (2 0 0 0 C17)
西安交通大学博士学位论文基金资助项目 (DFXJU2 0 0 0 -9)
关键词
多孔羟基磷灰石生物陶瓷
合成
特性
研究进展
Hydroxyapatite Porous ceramics Synthesis Characteristics Bioceramics
