摘要
本文对87例原发性高血压随机分为2组,用氨苯蝶啶(25mg)和氢氯噻嗪(12.5mg)制成复方胶囊和片剂对比治疗。胶囊组55例(男34例,女21例;年龄52±8yr),片剂组32例(男17例,女15例;年龄51±8yr),疗程4wk;2组剂量均以1粒bid开始,最大剂量为每天6粒。结果显示,2组降压幅度均较大(P<0.01),但胶囊组总有效率为82％,片剂组为91％,2组比较P>0.05。治疗后无严重不良反应。
Eighty seven patients with essential hypertension were randomized into two groups and treated with an antihypertensive compound (triamterene 25 mg and hydrochlorothiazide 12,5 mg, TH Co). Fifty five of them received TH Co in capsules (capsule group), while the other 32 patients was received TH Co in tablets (tablet group) as control. The two groups received an initial dosage 1 capsule or tablet bid, the maximum administration was 6 capsules or tablets/d, for 4 wk. Results revealed that the response rates were 82% in capsule group and 91% in tablet group. Both of them have similar effects on blood pressure.No serious adverse effects were observed, and were well tolerated.
出处
《新药与临床》
CSCD
北大核心
1991年第2期102-104,共3页
关键词
高血压
氨苯蝶啶
氢氯噻嗪
triam terene/therapeutic use
hydrochlorothiazide/therapeutic use
hypertension/drug therapy: drug combinations
