摘要
目的 :探讨肾素 血管紧张素系统与夜间高血压及血压昼夜节律的关系。方法 :分别对 30例正常人、30例轻中度高血压病患者 (必须同时具备夜间血压增高 )进行动态血压监测。同时采用放免法测定 8∶0 0、16∶0 0、2 2∶0 0、2∶0 0血浆肾素活性 (PRA)及血管紧张素Ⅱ (AngⅡ )浓度。结果 :30例患者与 30例正常人 2 4h动态血压变化曲线相似 ,均呈双峰 谷状。高肾素型患者PRA、所有患者和正常人的AngⅡ水平昼夜变化规律相似 ,都在 2∶0 0时最低 ,8∶0 0达最高 ,此后 16∶0 0、2 2∶0 0时依次降低。高肾素型患者不同时间点的PRA活性均高于正常人 ,并与平均动脉压 (MAP)呈正相关 (P <0 0 5 )。高血压患者不同时间点AngII水平均高于正常人 (P <0 0 5～ 0 0 1) ,与MAP呈正相关 (P <0 0 5 ) ;其夜间AngII水平与夜间SBP呈正相关 (P <0 0 1)。结论 :肾素 血管紧张素系统与夜间高血压及血压昼夜变化节律有关。
Objective:To investigate the relationship between rennin-angiotensin system and circadian rhythm of blood pressure in hypertensive patients with nocturnal hypertension. Methods: Ambulatory blood pressure monitoring (ABPM) was performed over a 24-hour period both in 30 normotensive subjects and 30 hypertensive patients with nocturnal hypertension. In the same period, plasma rennin activity and angiotensin II level were assayed by radioimmunoassay method in all of them at 8∶00, 16∶00, 22∶00 and 2∶00 respectively. Results: The curves of the circadian variation of the blood pressure in normotensive subjects and hypertensive patients were similar and presented two peaks and one trough. The plasma rennin activity in patients with PRA higher than normotensive subjects reached highest at 8∶00 and lowest at 2∶00 and was positively correlated with mean arterial pressure(P<0.05). In hypertensive patients, the plasma angiotensin II levels at 8∶00, 16∶00, 22∶00 and 2: 00 were all higher than normotensive subjects and positively correlated with mean arterial pressure(P<0.05), especially with systolic blood pressure(P<0.01). The plasma angiotensin II levels in hypertensive patients and normotensive subjects demonstrated same circadian variation, which had the highest value at 8∶00 and lowest value at 2∶00. Conclusion: The plasma rennin-angiotensin system may play important role in the pathogenesis of nocturnal hypertension and the regulation of circadian variation of blood pressure in hypertensive patients.
出处
《军医进修学院学报》
CAS
2002年第2期95-97,共3页
Academic Journal of Pla Postgraduate Medical School
