摘要
目的 :观察国产左旋卡尼汀 (L - carnitine,L - CN)辅助治疗冠心病患者心肌缺血和心律失常的临床疗效。方法 :选择冠心病患者 80例 ,随机分为两组 :对照组 (40例 )常规给予硝酸盐制剂、β受体阻滞剂或钙离子拮抗剂 ;L - CN组 (40例 )在常规治疗的基础上加用国产 L - CN治疗。 结果 :L - CN组与对照组相比 ,可更明显改善冠心病患者胸闷、胸痛和乏力症状 ;对心绞痛缓解的有效率分别为 86 .5 %和 5 7.5 % ,对 ECG缺血性 ST- T改善的有效率分别为 74 .2 %和 4 2 .9% ,均相差显著 (P<0 .0 1) ;治疗心律失常的总有效率分别为 6 7.9%和 35 .5 % (P<0 .0 5 ) ,且未见不良反应。 结论 :常规药物辅以 L - CN是治疗冠心病心肌缺血和心律失常的一种安全有效的新方法 ,可能与改善缺血心肌的能量代谢有关。
Objective: To observe the clinical effects of L carnitine in the treatment of myocardial ischemia and arrhythmia of coronary heart disease (CHD). Methods: Eighty cases of CHD patients randomly received routine treatment or L carnitine (3.0 g/d,iv×10 d) with routine therapy. Results: L carnitine effectivly improved a series of symptoms of CHD, such as chest distress ( P <0.05), chest pain ( P <0.05) and hypodynemia ( P <0.005). The effective rates of angina pectoris, ischemic ST T changes and arrhythmia on ECG of L carnitine group were 86.5%, 74.2% and 67.9% ( vs control 57.5%, 42.9% and 35.5%, P <0.05), respectively. No adverse reactions related to the drug were observed. Conclusion: L carnitine with routine therapy might be a safe way to treat myocardial ischemia and the complications caused by it, the mechanism might be related to improvement of energy metabolism of the ischemic myocardium.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2002年第5期548-550,共3页
Academic Journal of Second Military Medical University
基金
上海市卫生系统百名跨世纪优秀学科带头人培养计划基金 (970 47)
