摘要
目的 研究经肝动脉介入热疗对荷瘤兔肝肾功能及生命体征的影响 ,探讨介入热疗治疗肿瘤的安全性 .方法 建立可供实验研究的兔 VX2 移植性肝癌模型 10只 ;30 min内经兔肝动脉缓慢匀速注入 6 0℃生理盐水 4 0 m L .分别于灌注前及灌注后 1,3,5和 7d检查肝、肾功的动态变化情况 .结果 荷瘤兔的呼吸、心率、体温都有一定程度的改变 ,但 1h内均可恢复正常 ;AL T,AST于灌注后开始升高 (AL T7倍 ,AST2倍 ) ,之后逐渐恢复 ,1wk后恢复正常 ;胆红素、白蛋白及γ- GT无明显变化 .对肾功指标的监测表明 ,热疗对肾脏无明显影响 .结论 介入性热疗对荷瘤兔生命体征及肝肾功的影响是轻度的、可逆的 ,可以耐受 .
AIM To evaluate the injury of interventional thermo therapy on tumor bearing rabbit hepatic and renal tissues at 60℃ via hepatic artery. METHODS VX 2 carcinoma cells were inoculated into the hepatic parenchyma of white rabbits. Forty mL saline at 60℃ was perfused via hepaticartery in 30 min, 2 wk after the inoculation. Liver and kidney functions was checked before perfusion and 1, 3, 5 and 7 d after the perfusion. RESULTS Elevation of the serum ALT, AST levels was observed (ALT 7 times, AST 2 times) after the perfusion but reversed in a week, while Bil, Alb, γ GT, BUN, Cr, Uric Acid indicated no significant changes at all. Vital sign levels were observed during the perfusion but reversed in an hour. Hepatocellular degeneration was marked in the tumor free lobe, but was much severer in the tumor bearing lobe. CONCLUSION Inter ventional thermotherapy at 60℃ via hepatic artery may cause minor injury in tumor bearing rabbits.
出处
《第四军医大学学报》
北大核心
2002年第9期793-795,共3页
Journal of the Fourth Military Medical University
关键词
介入性热疗
肝功
肾功
肝肿瘤
荷瘤兔
治疗
interventional thermo therapy
liver function
renal function
liver neoplasms
tumor bearing rabbits
