摘要
用溶媒法制备了利福定固体分散物。经X—射线衍射实验证明,利福定在固体分散物中呈无定形或以分子状态分散于载体中。固体分散物2小时的体外溶出量和人体生物利用度分别较原药提高了88％和21.8％。
Rifandin Solid Dispersion (RSD) were prepared by using 'solvent method'. Result showed that Rifandin (R) was dispersed in carrier with amorphous or molecularity through x-ray diffract experiment. The disolution amount of R in RSD was 88％ more than that of untreated R in imitated gastric jules. The bioavailability of RSD was 21.8％ more than that of untreated R in human body.
