摘要
目的 研究高强度聚焦超声 (HIFU)治疗恶性实体肿瘤的安全性和有效性。方法 30例恶性实体肿瘤用单纯HIFU治疗 ,观察患者生命体征、主要脏器功能、影像学检查 (DSA、CT或MRI、SPECT等 )、穿刺活检、并发症和肿瘤转归的情况。结果 所有患者的生命体征平稳 ,心、肝、肾和肺功能正常 ,DSA示邻近的小动脉或小动脉以上的血管无损伤。平均随访 2 3.1个月 (10～ 38个月 ) ,存活2 6例 (87% )。 2 6例中 ,10例肿块完全消失 ;13例肿块缩小超过 5 0 % ,其中 8例行穿刺活检 ,病理证实为坏死的肿瘤细胞和 (或 )纤维组织 ;3例 (10 % )局部复发 ,其中 2例再次HIFU治疗 ,局部控制良好。2 6例中 ,有 5例出现新的远处转移 ,2例神经损伤 ,1例皮肤损伤。结论 单纯HIFU治疗恶性实体肿瘤是安全和有效的。
Objective To investigate the efficacy and side-effects of high intensity focused ultrasound (HIFU)in the treatment of malignant solid tumors. Methods Thirty such patients who refused surgery and or refractory to chemotherapy, were treated by HIFU alone, with the efficacy and side effects monitored in terms of vital organ signs observation, functional assay of important organs, imaging examinations: digital substraction angiography (DSA), CT, MRI, single photonemission computed tomography (SPECT), large core needle biopsy, complications or metastasis. Results After HIFU therapy, the vital signs remained stable and the function of heart, lung, kidney and liver was also normal. DSA images showed that small or larger arteries were not damaged. After a follow-up of 10-38 months (23.1 months), 26 patients (87%) have been alive. The volume of the tumor underwent complete regression in 10 patients. Shrinkage of tumor volume ≥50% was observed in 13. Eight of 13 patients were examined by large core needle biopsy, all showing necrosis and/or fibrosis though 3 patients (10%) had local recurrence. Two of these were retreated again by HIFU and the locally recurrent tumor became well controlled. New metastases developed in 5 patients after HIFU therapy. Two patients suffered from peripheral nerve injuries, most of which have recovered during the follow-up. However, one patient developed skin injury. Conclusion High intensity focused ultrasound alone is effective and safe in the treatment of malignant solid tumors.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2002年第3期278-281,共4页
Chinese Journal of Oncology
基金
国家"九五"科技重点攻关资助项目 ( 96 90 5 0 2 0 1)
国家自然科学基金资助项目 ( 39770 841)
关键词
单纯高强度聚集超声
治疗
恶性实体肿瘤
热切除
High-intensity focused ultrasound
Neoplasms/therapy
Neoplasms/thermal ablation
