摘要
A new compound was synthesized with 1,2,3 trimethoxybenzene as the starting material, followed by acylation of Friedel Crafts, bromination reaction, the nucleophilic N substitution of imidazole . For 2 bromo 1 (2,3,4 trimethoxyphenyl)ethanone in DMF,2 (1H imidazol 1 yl) 1 (2,3,4 trimethoxyphenyl) ethanone was obtained in yield of 62 7%. It was obtained that the best reaction condition which the molar ratio of bromo compound to imidazole will be 1∶5 and the reaction time will be 8 h under low temperature or room temperature. The structure of the product was confirmed by elemental analysis, 1H NMR and IR spectrum analysis.
Eight ( Z ) 2 (1 H imidazole 1 yl) 1 (2,3,4 trimethoxy)acetophenoxime esters(Ⅳ) were prepared in 62 1%～84 1% yield by reacting ( Z ) 2 (1 H imidazole 1 yl) 1 (2,3,4 trimethoxy)acetophenoxime(Ⅲ) with acyl chloride in the presence of methylene dichloride and triethylamine. The structures of the new compounds were proved by means of elemental analysis, IR and 1H NMR spectrum data. The relationship between the configuration and the spectral character was discussed.
出处
《应用化学》
CAS
CSCD
北大核心
2002年第5期491-493,共3页
Chinese Journal of Applied Chemistry
基金
元素有机国家重点实验室开放基金 (2 0 0 2 )
国家自然科学基金 (2 9462 0 3 )
贵州省优秀人才省长基金 (2 0 0 13 )资助项目
关键词
连苯三醚
咪唑
制备
trimethoxyacetophenoxime,ester,imidazole,synthesis,stero isomer
