摘要
目的探讨多巴胺受体D1基因 4 8A/G多态性与原发性高血压病相关性。方法运用聚合酶链反应一限制性片段长度多态性法 (PCR RFLP)分析了解 - 4 8A/G基因型在原发性高血压病组和正常血压对照组的分布情况。结果等位基因A ,G在原发性高血压病组和对照组的分布频率分别为 0 78,0 2 2和 0 86 ,0 14 ,基因频率分布符合Hardy Weinberg平衡 ,样本具有群体代表性 ,两组人群的基因型和等位基因频率存在明显统计学差异 (P <0 0 1,P <0 0 1)。原发性高血压组中G等位基因 ,舒张压明显高于A等位基因 (P <0 0 5 )。结论在中国人群中 ,多巴胺受体D1基因 4
Objective The present study examined the correlation between dopamine D 1 receptor gene 48A/G polymorphism and essential hypertension in a Chinese population. Methods The distribution of 48A/G polymorphism between primary hypertensive patients and normotensive subjects was identified with a polymerase chain reaction based restriction fragment length polymorphism protocol. Results The allelicfrequencies were 0 78 for the A allele and 0 22 for the G allele in EH patients, 0 86 for the A allele and 0 14 for the G allele in normotensive subjects. The allelic frequencies were in Hardy Weinberg equilibrium.\ Significant differences in the genotype distribution ( P< 0 01) and allelic frequencies ( P< 0 01) between hypertensive and normotensive subjects were seen.\ and the diastolic blood pressure for G allele was higher significantly than that for A allele in hypertensive subjects ( P< 0 05). Conclusion These results suggest that the -48A/G polymorphism of human dopamine D 1 receptor correlates significantly with primary hypertension in the Chinese population.
出处
《高血压杂志》
CSCD
2002年第3期249-251,共3页
Chinese Journal of Hypertension
