摘要
用双盲、对照法,观察病毒唑对发病4天以内的165例流行性出血热患者(治疗组91例、对照组74例)病程中外周血白细胞及血小板的变化。用药后,病毒唑组增高的白细胞的下降,降低的血小板的回升,在第2,4、6研究日,较对照组明显(P<0.05及<0.01)。类白血病反应,亦较对照组低(P<0.01)。淋巴细胞百分数及异型淋巴数,分别在第2、4、10研究日较对照组低(P<0.05)。表明:病毒唑具有抗-EHF病毒感染的作用。如在病程早期应用,可阻断病情的发展,减轻疾病的严重程度,从而降低病死率。
With a double-blind,placebo-controlled design,we observed the changes of white blood cell system and platelelet among the EHF patients(91 cases treated with ribavirin and 74 with placebo).We noticed a very rapid down-back of white blood cell count and up-back of platelet in the ribavirin- treated patients,which had abnormally increased and decreased respective- ly in the course of disease.On the 2nd,4th and 6th illness day,there are significant differences between the two groups of patients in two parameters,ie:P<0.05(WBC)and P<0.01(Plat.)respectively.As to the leukemia-like reaction its occurrence in ribavirin-treated group is statistic- ally less than that in the placebo group.Both percentages of lymphocytes and the atypical lymphocyte count in the ribavirin group are smaller than those in the placebo group.The significant difference was observed on the 4th,11th(the percentage of lymphocytes) and the 2nd(aty- pical lymphocyte count)treatment day,respectively(P<0.05).These results indicate that ribavirin has the preventive effect on the EHF virus infection.The usage of it in the early phase of this disease will block the development of the illness,decrease the severity and the mortality of this disease.
关键词
流行性出血热
病毒唑
白细胞
hemorrhagic fever,epidemic/DT
ribavirin/PD
ribavirin/DE
