摘要
实验以蟾蜍离体脊髓为模型,研究锂对中枢神经系统的作用,发现锂能增强刺激背根在腹根诱发的反射性电位(DR-VRR),且抑制刺激背根在邻近背根诱发的背根电位(DR-DRP);锂对蟾蜍离体脊髓作用的阈浓度在4mmol/L以下。用蔗糖间隙法记录脊髓背、腹根极化水平,发现锂能引起腹根去极化,且作用不被Mg^(++)阻断;锂也能引起背根去极化,但去极化能被Mg^(++)阻断;锂还能抑制背、腹根上的强直后超极化。锂作用的基本机理可能与Na^+-K^+泵的转运有关。
The effect of lithium on the reflex respons was ob-served on the isolated spinal cord of the toad It wasfound that lithium could inercase the amplitude ofDR--VRR and depress that of DR--DRP The threshold corcentrations for theeffect of lithium were below 4 mmol/L With the sucrosegap technigue to record the depolarization levels ofventral and dorsalroots, lithum could induce thedepolarization of ventral root which was not blockedby Mg^(++), and it could also inducc the depolarization ofdorsal root but the effect could be significantly reducedby Mg^(++). The postetanic hyperpolarization of vertral anddorsal roots were inhibted by lithium significantly,tooThe basic mechanism of the action of lithium might berelated to the transport function of theNa^(+)--K^(+) pump.
出处
《西安医科大学学报》
CSCD
1991年第2期101-104,115,共5页
Journal of Xi'an Medical University(Chinese)
关键词
锂
蟾蜍
离体脊髓
强直后超极化
lithium
toad isolated spinal cord
postetanic hyperpolarization
