摘要
目的 为尘肺的发病机制研究、治疗提供无损伤的家兔尘肺动物模型和肺灌洗方法。方法 采用气管插管向家兔气管内注入直径≤ 5 μm的粉尘 ,用改进的灌洗导管进行肺灌洗。结果 染煤尘家兔全肺多处出现点状和片状黑色尘斑 ,成纤维细胞增生 ;染矽尘家兔全部发现矽结节且有多处融合。X线摄片证实染尘家兔两肺存在不规则小阴影或片状融合阴影及类圆形阴影等。灌洗液回收率为 89%～94%。结论 采用气管插管和改进的灌洗导管制备尘肺模型和进行肺灌洗 ,方法简便、安全、无损伤。
Objective To provide an intact rabbit pneumoconiosis model and a method of lung lavage for studying the pathogenesis and treatment of pneumoconiosis. Methods The dust particles(≤5 μm diameter) were poured into the trachea of rabbit by trachea spile.The lung lavage of rabbit was carried out by the improved trachea catheter method. Results The rabbit lungs exposed to coal dust showed many black dust spots and there were proliferation of fibroblasts.The rabbit lungs exposed to silica dust showed nodules and several fusing nodules.The X-ray film showed that there were small irregular shadows,or fusing together into flake-like or round shadows in both lungs.The recovery rate of the lung lavage was 89%～94%. Conclusion The model made by trachea spile and the method of lung lavage by the improved trachea catheter were simple,safe and without being injured.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2002年第2期131-133,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
基金
河南省自然科学基础研究资助项目 ( 9712 0 0 30 6 )
