摘要
为了解 0～ 15岁健康人群及产妇血清特异性百日咳IgG抗体水平 ,随机选取山西省太原市 45 8人作为检测对象 ,根据年龄分为 9个组 :脐血组 (5 8例 )、0～ 5月龄 (33例 )、6～ 11月龄 (6 2例 )、1～ 2岁 (5 0例 )、3～ 5岁 (5 0例 )、6～ 8岁 (5 0例 )、9～ 12岁 (4 9例 )、13～ 15岁 (4 8例 )、产妇 (5 8例 )。其中有 5 4例为配对脐血组及产妇组。取血清应用酶联免疫吸附试验 (ELISA)测定百日咳特异性IgG抗体。结果表明 ,百日咳IgG抗体水平 1～ 2岁最高 ,13～ 15岁最低 ,0～ 5月龄处于较低水平。配对脐血组及产妇组的百日咳IgG抗体水平具有良好的相关性 (r =0 741,P <0 0 1)。百日咳抗体水平在 13～ 15岁最低 ,<6月龄次之 ,1～ 2岁最高。为根除婴儿百日咳的主要传染源 ,对年长儿及成人进行百日咳加强免疫是必要的。
For detecting the antibody level of Bordetella pertussis in 0～15 year old healthy children and in puerpera,a total of 458 healthy individuals were randomly selected from Taiyuan of Shanxi Province.They were divided into nine groups according to their age,that were Group newborns(58 individuals, collecting their umbilical cord blood);Group puerpera(58);Groups aged 0～5 months(33),6～11 months(62),1～2 years(50),3～5 years(50),6～8 years(50),9～12 years(49)and 13～15 years(48). Specific IgG antibody was tested by ELISA,the sonicated B.pertussis bacteria was used as coating antigen.The results showed that the highest specific IgG antibody level was seen in Group aged 1-2 years concurrently given booster doses of diphtheria-tetanus toxoids-pertussis(DTP)vaccine,it decreased gradually with the lapse of time,showing the lowest in Group aged 13～15 years.Antibody level taking the second place was seen in infants aged≤1 year after administration of primary 3～doses of DTP vaccine.There was a good correlation between specific IgG antibodies of pertussis of umbilical cord blood of newborns and their matched mothers(r=0.741,P<0.01).Pertussis is likely to infect infants,older children and young adults,the booster immunization against pertussis to them is necessary.
出处
《中国计划免疫》
2002年第3期141-143,共3页
Chinese Journal of Vaccines and Immunization
