摘要
Rh血型系统是人类较为复杂和重要的血型系统。它有两个同源结构基因串联排列在1p34 .3- 36 .1,编码的 Rh蛋白为有 12个跨膜域的红细胞膜蛋白。Rh抗原有很多变异体 ;Rh D阴性个体存在 3种遗传多态性。Rh血型系统在临床输血及新生儿溶血病 (hemolytic disease of the newborn,HDN)中意义重大 ,可利用 PCR进行 Rh基因分型方法对胎儿进行产前诊断 ,但此方法仍有一定缺陷。需要对 Rh血型系统进行更深入的认识 ,以解决这一问题。
The Rh blood group system is one of the most complex and important systems known in humans. It has two homologous structure genes in tandem on 1p34. 3-36.1 that encode Rh protein. The Rh protein is a membrane in red blood cell that has 12 transmembrane spans. Rh antigens have many variants; there are three genetic polymorphisms in the RhD-negative individual. The Rh blood group system is of great significance in clinical transfusion and hemolytic disease of the newborn (HDN). Rh PCR genotyping is used for prenatal diagnosis in fetus, but still it has some defects, and in this connection further knowledge about Rh system will be necessary to solve the problem.
出处
《中华医学遗传学杂志》
EI
CAS
CSCD
2002年第3期246-249,共4页
Chinese Journal of Medical Genetics
