摘要
目的 :探讨碳酸锂 (Li2 CO3 )对放化疗肿瘤患者有无抗遗传及抗氧化损伤作用。方法 :给予临床放化疗肿瘤患者Li2 CO3联合用药治疗 ,采用单细胞凝胶电泳试验、外周血淋巴细胞微核试验及生化试验方法测定DNA损伤、微核率 (MNF)、超氧化物歧化酶 (SOD)和谷胱苷肽过氧化物酶 (GSH Px)活力、疏基 ( SH)和丙二醛 (MDA)含量。结果 :随Li2 CO3 疗程及剂量的增加 ,联合用药组与单纯放化疗组相比DNA断裂分级、慧星尾长、MNF显著降低 (P <0 .0 5 ) ;SOD、GSH Px活力、 SH含量、WBC总数显著增高 (P <0 .0 1)。结论 :Li2 CO3 可降低肿瘤患者遗传损伤程度 ,提高其抗氧化酶活性 ,降低抗癌药物的骨髓抑制作用。
Purpose: To observe the inhibitory effect of lithium carbonate (Li-2CO-3) on genetic and oxidative damage in cancer patients. Methods: The single cell gel electrophoresis assay (SCGE), micronucleus test were used to measure DNA and chromosomal damage. At the same time, SOD, GSH-Px, and-SH and MDA were detected by biochemical tests. Results: The genetic damage of peripheral blood cells in cancer patients was relieved gradually with Li-2CO-3 treatment, and the activity and content of the anti-oxidative material and WBC number increased significantly. Conclusion: Li-2CO-3 can inhibit genetic damage, increase the ability of anti-oxidation and relieve the myellogenic inhibition.
出处
《癌变·畸变·突变》
CAS
CSCD
2002年第2期98-101,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
贵州省自然科学基金 (G95 6 )
关键词
碳酸锂
肿瘤患者
淋巴细胞
遗传损伤
氧化损伤
lithium carbonate
cancer patient
lymphocyte
genetic damage
oxidation damage
