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线粒体通透性改变与细胞凋亡 被引量:3

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摘要 细胞凋亡受线粒体的调控 ,线粒体通透性改变 (MPT)在凋亡中起着关键作用。Bcl 2家族蛋白等许多因子作用于线粒体 ,使线粒体膜上的通透性改变孔 (PTP)开放 ,线粒体跨膜电位 (ΔΨm)降低甚至崩解 ,线粒体释放出细胞色素c、凋亡诱导因子(AIF)等凋亡相关因子 ,激活caspase级联反应 ,导致细胞凋亡。
作者 李贵昌 吴坤
出处 《癌变·畸变·突变》 CAS CSCD 2002年第2期127-130,共4页 Carcinogenesis,Teratogenesis & Mutagenesis
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