摘要
目的 :评价蛋白涂层支架携带血管内皮生长因子 (VEGF)预防冠状动脉成形术后再狭窄的效果。方法 :金属支架涂层为胶联明胶制成。应用标准球囊导管技术 ,将包被有VEGF的涂层支架置入小型猪 (n =10 )冠状动脉前降支中段 ,以相同方法置入单纯蛋白涂层支架作为对照组 (n =10 ) ,支架与血管直径之比为 1.1～ 1.3∶1。结果 :在支架置入后 3个月时冠状动脉造影显示 :VEGF组无再狭窄发生 ,而对照组均发生显著的再狭窄。组织病理学形态分析结果显示 :VEGF组新生内膜面积 (1.8± 0 .6 )mm2 ,平均百分狭窄面积 (2 5 .9± 6 .5 ) % ,平均管腔狭窄百分数 (40 .4± 13.7) % ,均较对照组〔分别为 (2 .6± 0 .7)mm2 ,P <0 .0 5 ;(93.1± 11.5 ) % ,P <0 .0 1;(88.2± 14 .4 ) % ,P <0 .0 1〕小 ;内膜面积 /中膜面积比值 ,治疗组较对照组减少了 5 5 .3%。结论 :在小型猪模型使用蛋白涂层包被VEGF支架 ,能预防内膜过度增殖 ,从而预防再狭窄的发生。
Objective:To assess the effect of vascular endothelium growth factor carried by protein coated metallic stents in inhibiting neointimal hyperplasia after coronary angioplasty.Method: The stent was coated by cross linked gelatin and mounted on 3.0 mm PTCA balloon. Ten VEGF stents were implanted into the middle segment of LAD in 10 animals, another 10 protein coated stents were also used into the middle segment of LAD in 10 animals. The ratio of balloon to vessel diameter was 1.1 ～ 1.3 :1.Result: After the third months of stenting, the coronary angiograms showed that there was no restenosis in all animals of VEGF group while restenosis developed in all animals of the control group. Morphmetric analysis showed that neointimal area ( 1.8 ± 0.6 mm 2), mean percentage of area stenosis ( 25.9 ± 6.6 %) and mean percentage of lumen diameter stenosis (40±17%) in VEGF group were significantly less than those ( 2.6 ± 0.7 ,P< 0.05 ; 93.1 ± 11.5 %, P< 0.01 ; 88.2 ±14% ,P< 0.01 ) in control group. The proportion of the neointimal area to media area(I/M) reduced to 55.3 % in VEGF group.Conclusion: VEGF in protein coated metallic stents significantly inhibites the intimal hyperplasia after coronary angioplasty in min swine model.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2002年第5期223-225,共3页
Journal of Clinical Cardiology
